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Sunday, April 20, 2014

Closing Surgical Incisions With A Paintbrush And Nanoparticles

From the German Chemical Society journal Angewandte Chemie...

"Stopping bleeding (hemostasis), preventing body fluid leakages, wound closing, and organ repair are everyday challenges in medical and surgical practice. Sutures and staples are standard and efficient tools. Still, suturing can be demanding in inaccessible body regions or within minimally invasive surgery. Moreover, sutures are traumatic to tissues especially soft tissues such as liver, spleen, kidney, or lung."

"Polymer tissue adhesives require complex in vivo control of polymerization or cross-linking reactions and currently suffer from being toxic, weak, or inefficient within the wet conditions of the body. Herein, we demonstrate using Stöber silica or iron oxide nanoparticles that nanobridging, that is, adhesion by aqueous nanoparticle solutions, can be used in vivo in rats to achieve rapid and strong closure and healing of deep wounds in skin and liver. Nanoparticles were also used to fix polymer membranes to tissues even in the presence of blood flow, such as occurring after liver resection, yielding permanent hemostasis within a minute. Furthermore, medical devices and tissue engineering constructs were fixed to organs such as a beating heart. The simplicity, rapidity, and robustness of nanobridging bode well for clinical applications, surgery, and regenerative medicine."

In other words, it looks like very soon there will be a way to heal wounds and repair organs virtually instantaneously. Ain't science great?

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